For 25 years, the Fugue, a string quartet, has wowed music-lovers with its skilled performances. However, as the musicians prepare to celebrate a milestone season together, cellist Peter (Christopher Walken) drops a bombshell on his comrades: he has Parkinson's disease and must soon retire. In the fallout from the shocking announcement, competing egos clash, long-simmering resentments bubble to the surface, and marital infidelity rears its ugly head.